At the moment, there are two airlines flying to San Francisco. Go through the results to find the right flights for you – you can adjust the filters to see find even more flights to San Francisco.
The most popular airlines offering flights to San Francisco are Alaska Airlines & JetBlue. Alaska Airlines is the most popular one, but that doesn’t mean their flights will be the cheapest. If you can't find a flight time that suits you, why not look at flying out from a different airport?
The distance between New York La Guardia Airport to San Francisco is 4144 km. Normally, it takes about 9 hrs 30 mins to fly, and you can definitely expect the journey to be at least 9 hrs. You can see the various flight times in the results.
Searching by month, for instance, will show you the best time of the week to fly.