We've gone through lots of different flights, to help you find the cheapest way to get from London Heathrow to Cape Girardeau. You can choose from zero airlines.
If you can't find a flight time that suits you, why not look at flying out from a different airport?
The distance between London Heathrow to Cape Girardeau is 6816 km. You can see the various flight times in the results.
Searching by month, for instance, will show you the best time of the week to fly.